I think the issue of Brenda being a game designer and a woman is a Who Cares. But there are issues that have to do with women in game development that are not a Who Cares.
For instance, a recent study claimed that women are turned off by common user interfaces in computer software... is that a possible reason why qualified women who know math and could program just aren't majoring in computer programming?
Sande Chen
http://damedev.blogspot.com